{"product_id":"night-time-relax-formula","title":"Night-Time Relax Formula","description":"\u003cp\u003eA daily supplement to promote a better night’s sleep\u003c\/p\u003e\n\u003cp\u003eLemon Balm \u0026amp; Lavender help to find a better sleep\u003c\/p\u003e\n\u003cp\u003eHops have a soothing effect \u0026amp; promote good sleep\u003c\/p\u003e\n\u003cp\u003eB6 contributes to the regulation of hormonal activity\u003c\/p\u003e\n\u003cp\u003eBiotin, Folic Acid \u0026amp; B12 contribute to normal psychological function\u003c\/p\u003e\n\u003cp\u003eB12 contributes to the normal functioning of the nervous system\u003c\/p\u003e\n\u003cp\u003eChromium contributes to the maintenance of normal blood glucose levels\u003c\/p\u003e\n\u003cp\u003eWith authentic New Zealand Manuka honey powder MGO 300 and Bee Pollen\u003c\/p\u003e\n\u003cp\u003eContains: 30 capsules\u003c\/p\u003e\n\u003ch1\u003eDescription\u003c\/h1\u003e\n\u003cp\u003eA daily food supplement to help you find a better sleep. Made with botanicals Lemon Balm, Lavender \u0026amp; Hops. This formula also provides vitamins and minerals to maintain psychological and nervous function, regulate hormone activity and blood glucose levels, in addition to mental performance and stress management which will help you relax and unwind in order to get a great night’s sleep.\u003c\/p\u003e\n\u003cp\u003eThe Manuka honey is sourced from our very own Manuka Doctor hives nestled in the luscious green mountains of New Zealand. The honey is freeze dried into powder form and added to our formula which is lovingly made in the UK to the very highest standard. The MGO (methylglyoxal) level in Manuka Honey is derived from DHA (dihydroxyacetone) which is naturally present in the nectar of the Manuka Bush.\u003c\/p\u003e\n\u003cp\u003ePlant-derived capsule shell\u003c\/p\u003e\n\u003ch1\u003eWhy it works\u003c\/h1\u003e\n\u003cp\u003eLemon Balm (Melissa officinalis) is a frequently used sleeping remedy for the elderly (lutoMSki, 2000). A 15-day pilot study showed that in a stressed group, Lemon balm leaf extract reduced anxiety and insomnia related to anxiety. In another study it was found that Lemon balm extract significantly reduced the time of falling asleep and extended sleep time. It was also shown that the mixture with lavender extract (Lavandula angustifolia) had a synergistic effect in terms of length of falling asleep and the sleep itself, which may be important in the treatment of insomnia (hajhaSheMi and Safaei, 2015). [1]\u003c\/p\u003e\n\u003cp\u003eA separate study into the extract of stems and flowers of Lavender produced significant sedative effect compared to diazepam. [2]\u003c\/p\u003e\n\u003cp\u003eThere is strong evidence that Hops (Humulus lupuls L.) have been used safely for over 30 years to relieve mental stress and to aid sleep and so have been approved by the Committee on Herbal Medicinal Products (HMPC) on their ‘traditional use’. [3]\u003c\/p\u003e\n\u003cp\u003eVitamin B6 plays an important role in the synthesis of amino acid GABA, tryptophan, and serotonin all of which impact sleep. [4] GABA is produced naturally in the brain. When levels of GABA increase, it suppresses the central nervous system to reduce excitability and, when bound, produces a calming effect that may support a reduction in stress anxiety, and sleeplessness. [5,6] Tryptophan is an amino acid that plays a role in the production of serotonin, the “happy hormone” that helps stabilize our mood. For this reason, vitamin B6 deficiencies have been linked to irritability, emotional disturbances, and disrupted sleep. [7,8]\u003c\/p\u003e\n\u003cp\u003eThere is some evidence to support B12 as a regulator of the sleep-wake cycle due to its role in modulating production of melatonin, the sleep hormone, and keeping the circadian rhythms in sync. [9] The vitamin helps increase the production of melatonin during the night-time hours, as well as release it earlier, making it easier to fall and stay asleep. A study published in Neuropsychopharmacology looked at the effects of methyl- and cyanocobalamin on circadian rhythms, well-being, alertness, and concentration in healthy volunteers [10]. They found that methyl B12 (methylcobalamin) was more effective for improving daytime alertness and concentration and shortened and improved sleep patterns in healthy volunteers.\u003c\/p\u003e\n\u003cp\u003eSources\u003cbr\u003e [1] Katarzyna Swiader et al. The therapeutic properties of Lemon balm (Melissa officinalis): Reviewing novel findings and medical indications. Journal of Applied Botany and Food Quality. Vol 92:327-335. November 2019.\u003cbr\u003e [2] Alnamer, R.; Alaoui, K.; Bouidida, E.H.; Benjouad, A.; Cherrah, Y. Sedative and hypnotic activities of the methanolic and aqueous extracts of Lavandula officinalis from Morocco. Adv. Pharmacol. Sci. 2011, 2012.\u003cbr\u003e [3] EMA. Hop Strobile, Humulus lupulus L. Flos; EMA\/HMPC\/304459\/2016; EMA: Amsterdam, The Netherlands, 2016\u003cbr\u003e [4] https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4772032\/\u003cbr\u003e [5] https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09637480802558508\u003cbr\u003e [6] https:\/\/link.springer.com\/article\/10.1007\/s00726-011-1206-6\u003cbr\u003e [7] https:\/\/pubmed.ncbi.nlm.nih.gov\/9625217\/\u003cbr\u003e [8]https:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/0031512518770326?journalCode=pmsb\u0026amp;\u003cbr\u003e [9] Okawa M, Mishima K, Nanami T, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13(1):15-23.\u003cbr\u003e [10] Mayer G, Kröger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology. 1996;15(5):456-464.\u003c\/p\u003e\n\u003ch1\u003eDirections \u0026amp; Warnings\u003c\/h1\u003e\n\u003cp\u003eTake one capsule, one hour before bed. Do not exceed this recommended daily dose. This product should not be used as a substitute for a varied, balanced diet and healthy lifestyle. Please keep out of reach from children.\u003c\/p\u003e\n\u003cp\u003eDiscontinue use and consult a doctor if adverse reactions occur. Avoid this product if you have allergies to pollen, bees or bee products. Do not use this product without first consulting with your doctor if you are under medical supervision, on prescribed medication, pregnant, breastfeeding, have asthma or related allergies.\u003c\/p\u003e\n\u003ch1\u003eIngredients\u003c\/h1\u003e\n\u003cp\u003eHops 7.5:1 Extract, Tryptophan Powder, Freeze Dried Manuka Honey (Maltodextrin), Vegetable Capsule Shell (Hydroxypropyl Methylcellulose Capsule), Zinc Citrate Dihydrate, Griffonia Seed 8:1 Extract (Griffonia Simplicifolia), Bulking Agent (Microcystalline Cellulose), Vitamin B5 (Calcium Pantothenate), Vitamin B6 (Pyridoxine Hydrochloride), Lemon Balm 4:1 Extract, Chamomile 12:1 Extract, Anti-Caking Agents (Silicon Dioxide, Magnesium Stearate), Lavender Herb 10:1 Extract, Montmorency Cherry 50:1 Extract, Chromium (Chromium Picolinate), Vitamin B9 (L-5-Methyletetrahydrofolate MTHF), Biotin (D-Biotin), Vitamin B12 (Methylcobalamin).\u003c\/p\u003e\n\u003cp\u003eNo Added Flavourings or Colourings * Gluten * Nuts * GMO’s * Dairy or Yeast\u003c\/p\u003e\n\u003ch1\u003eProduct Information\u003c\/h1\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0026\/7229\/6002\/files\/Manuka-Plus_Night-Time-Relax_Capsules_NIP_Web.jpg?v=1677498109\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/p\u003e","brand":"Manuka Doctor","offers":[{"title":"Default Title","offer_id":55951608906054,"sku":"MD5240AT","price":11.25,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/0888\/8118\/files\/ManukaPlus_NightTimeRelax_Capsules_Front_Web.jpg?v=1770630886","url":"https:\/\/www.manukadoctor.at\/products\/night-time-relax-formula","provider":"Manuka Doctor AT","version":"1.0","type":"link"}